Value of Dual Assessment of Carcinoembryonic Antigen and Fluorine-18-Fluoro-Deoxyglucose Positron Emission Tomography in Colorectal Cancer Recurrence

Saeed Mohammed Bafaraj 1 *
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1 Department of Diagnostic Radiology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia
* Corresponding Author
EUR J BASIC MED SCI, Volume 5, Issue 2, pp. 25-30. https://doi.org/10.21601/ejbms/9232
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ABSTRACT

Globally, colorectal cancer is a common medical problem and improvement of survival in patients with colorectal carcinoma could be achieved by identifying disease recurrence and progression, as well as by specifying their treatment planning. The use of various biomarkers associated with radio diagnosis techniques is not common in daily clinical practice. The aim of the present study was to evaluate the usefulness of dual assessment of FDG-PET and CEA in detecting recurrence of colorectal carcinoma in patients subsequent to colonic resection or rectal amputation. One hundred sixty patients, 99 males and 61 females, the mean of their age was 55.76 ± 12.25 years with suspected recurrent colonrectal cancer (CRC) after previous colonic resection or rectal amputation for CRC were included in this prospective study from February 2011 to March 2015. The inclusion criteria were: histopathologically confirmed colorectal adenocarcinoma, curative resection of the primary tumor, at least 3 months before and availability for follow-up after 18F-FDG PET/CT and CEA for at least 12 months. The CEA levels were measured within the time of the FDG PET/CT study. Only 132 patients were confirmed by histopathology or 6 month clinical follow up had local recurrence or metastasis (47 patients were confirmed had Intra-abdominal extra-hepatic recurrence , 80 patients had extra-abdominal and/or hepatic recurrence , 30 patients had other form of recurrence (17 patients had metastasis at other sites as the neck, long bones , mediastinal lymph nodes and multiple metastases) .The PET/CT diagnosis of recurrence and metastasis in CRC patients included in the study. Out of 160 patients after CRC resection, 126 patients were diagnosed by PET/CT as true-positive cases (25.62% Stage II /53.13% and I Stage III/IV) and 34 patients as negative cases (21.25 %). The sensitivity of monitoring the recurrence and metastasis of patients with CRC by PET/CT was 95.45 %. However, the diagnostic value of CEA levels for recurrence and metastasis in CRC patients included in the study proved that 102 patients had increased value of CEA (63.8%) and 58 patients (36.2%) had normal CEA value. The sensitivity of the CEA levels for monitoring the recurrence of the patients with CRC was 77.27 %. The sensitivity of the 18F-FDG PET/CT scan is superior to CEA in detection of colorectal cancer recurrence and dual assessment is important in treatment planning.
Keywords: carcinoembryonic antigen, Fluorine-18-fluoro-deoxyglucose positron emission tomography, colorectal cancer recurrence

CITATION

Bafaraj SM. Value of Dual Assessment of Carcinoembryonic Antigen and Fluorine-18-Fluoro-Deoxyglucose Positron Emission Tomography in Colorectal Cancer Recurrence. Eur J Basic Med Sci. 2015;5(2):25-30. https://doi.org/10.21601/ejbms/9232

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