Pineal Parenchymal Tumor of Intermediate Differentiation: A Brief Report

Halil Kıyıcı 1 * , Burcu Sanal 1
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1 Selcuk University, Selcuklu Faculty of Medicine, Pathology Department
* Corresponding Author
EUR J BASIC MED SCI, Volume 2, Issue 1, pp. 30-33. https://doi.org/10.21601/ejbms/9170
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ABSTRACT

The 2007 WHO classification of tumors of the central nervous system identified “pineal parenchymal tumor of intermediate differentiation” (PPTID) as a new pineal parenchymal neoplasm, located between pineocytoma and pineoblastoma as grade II or III [1]. Because of the small number of reported cases, the classification of pineal parenchymal tumors (PPT) is still a matter of controversy. We report a case of PPTID. A 23 years old female patient was admitted to hospital with a complaint of headache. A mass, 3.5 cm in diameter was found at the pineal region. Following operation, histopathological examination of the surgical specimen revealed a highly cellular tumor, with diffuse pattern and low mitotic activity (1 /10HPF). There was no evidence of necrosis or pineocytomatous rosettes. Immunhistochemical examination showed strong and diffuse staining for synaptophysin. There was no expression of GFAP and chromogranin A. Ki-67 proliferation index was 7%. An accurate grading is essential for these rare tumor, because optimal therapeutic management and prognosis depend on the histopathological grading. Significance of intraoperative evaluation for pineal tumors is still questionable. As a conclusion, it is preferable to use different terminologies for grade II and grade III PPTID.
Keywords: pineal, parenchymal, tumor, intermediate differentiation, grading

CITATION

Kıyıcı H, Sanal B. Pineal Parenchymal Tumor of Intermediate Differentiation: A Brief Report. Eur J Basic Med Sci. 2012;2(1):30-3. https://doi.org/10.21601/ejbms/9170

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