Genotyping of Hepatitis C Virus (HCV) in Infected Patients from Yemen

Hassan A. Al-Shamahy 1, Sami Sultan Ahmed Abdu 2
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1 Department of Medical Microbiology, Faculty of Medicine and Health Sciences, Sana’a University
2 Al-Awalagy Medical Laboratory
EUR J BASIC MED SCI, Volume 3, Issue 4, pp. 78-82.
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Hepatitis C virus has been considered to be one of the most important devastating causes of chronic hepatitis, cirrhosis, and hepatic cellular carcinoma. In this area, the epidemiology of hepatitis C is not well understandable in spite it was found to be endemic in Yemen.The distribution of hepatitis C virus (HCV) genotypes in the Yemen is unknown, so a molecular study was carried to investigate the prevalence of Hepatitis C virus (HCV) genotypes in HCV infected population of Sana’a, Yemen. A total of 502 HCV-positive clinical specimens (serum, EDTA plasma) with viral loads above 2,000 IU/ml were collected for genotyping. Genotyping of 502 samples revealed four different genotypes including 1 (1a and 1b), 2a, 3 (3a) and 4. The most prevalent genotype was 4 with rate of 63.7% followed by genotype 1a+1b (26.9%), 2a (7.6%) and 3a (1.8%). Genotypes 5 and 6 were not found in our patients. The predominance of HCV genotype 4 in our population confirms the predominance of HCV genotype 4 in Yemen and similar to most of the Arab countries in the Middle East.


Al-Shamahy HA, Abdu SSA. Genotyping of Hepatitis C Virus (HCV) in Infected Patients from Yemen. Eur J Basic Med Sci. 2013;3(4):78-82.


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