Can COVID-19 Be a Potential Risk Factor for Voriconazole-Induced Hyperkalemia?

Salma Ben Hmida 1 * , Ichrak Bougharriou 1, Hana Chaabouni 1, Hanen Ghozzi 2, Khaled Zghal 2, Mounir Benjemaa 1
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1 Infectious Diseases Department, Hedi Chaker Hospital, University of Sfax, TUNISIA
2 Pharmacology Department, University of Sfax, TUNISIA
* Corresponding Author
EUR J BASIC MED SCI, Volume 11, Issue 4, pp. 46-51.
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Voriconazole is an antifungal agent that is commonly used to treat fungal infections. Like any drug, it can cause side effects, especially in the case of overdose. Few cases of hyperkalemia have been reported, which presented when the serum voriconazole level was elevated or when there was voriconazole-drug interaction. We present here a case of voriconazole-induced hyperkalemia, prescribed for an oral candidiasis due to Candida glabrata in a patient hospitalized for severe COVID-19 pulmonary infection. Inflammation due to COVID-19 may play a role in the variability of voriconazole concentrations and then in hyperkalemia.


Ben Hmida S, Bougharriou I, Chaabouni H, Ghozzi H, Zghal K, Benjemaa M. Can COVID-19 Be a Potential Risk Factor for Voriconazole-Induced Hyperkalemia?. EUR J BASIC MED SCI. 2021;11(4):46-51.


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